Much has been written about the emerging therapy area that is renal denervation, and while there is the odd nay sayer out there, the evidence is building that it may well become part of the landscape of commonly used procedures in the treatment of refractory hypertension. And, helping it on its way, now it seems the procedure is getting positive vibes from the healthcare economic lobby as one of the leading corporate pioneers, Medtronic issues news of a soon-to-be published paper suggesting it’s a cost effective treatment too.
Medtronic, Inc. has announced findings from a health-economic analysis published online before print in The Journal of the American College of Cardiology that suggest the company’s Symplicity™ renal denervation system is a cost-effective treatment strategy for patients with treatment-resistant hypertension.
The Markov model used for this analysis estimated the discounted incremental cost-effectiveness ratio (ICER) of renal denervation with the Symplicity system in U.S. dollars per quality-adjusted life year (QALY) was $3,071 – well below the recognised threshold of $50,000/QALY.
The model also projected that, over 10 years, renal denervation plus Standard of Care (SoC), treatment with three or more anti-hypertensive medications, could reduce cardiovascular mortality by 30 percent and all-cause mortality by 15 percent compared to SoC alone. Renal denervation with the Symplicity system was projected to substantially reduce 10-year and lifetime probabilities of stroke, myocardial infarction (MI), coronary heart disease (CHD), heart failure and end-stage renal disease (ESRD).
The model also found that median survival rates were estimated as 18.4 years for renal denervation with the Symplicity system compared to 17.1 years for SoC, and that cardiovascular end points might decrease by 21 percent to 32 percent over 10 years.
“These results suggest that renal denervation with the Symplicity system is a cost-effective treatment strategy for resistant hypertension at a value substantially lower than the commonly accepted threshold,” said Brent Egan, M.D. study co-author, professor, department of medicine, Medical University of Southern Carolina (MUSC). “Moreover, this health-economic model indicates that renal denervation with the Symplicity system may decrease mortality and reduce cardiovascular events in treatment-resistant patients, which would offer a major advancement in our approach to addressing this growing and costly disease.”
“Our reliance on widely established multivariate risk equations, such as those from the Framingham heart study, allowed us to comprehensively assess and confirm the robustness of the model’s projections across a wide range of cardiovascular risk profiles,” said Jan B. Pietzsch, Ph.D., senior author and study director, president and CEO, Wing Tech Inc.
“As our clinical trial program and this cost-effectiveness analysis indicate, renal denervation with the Symplicity system represents an opportunity for Medtronic to help millions of patients worldwide while providing cost-effective solutions to our customers and healthcare systems,” said Sean Salmon, Senior Vice President and President, Coronary & Renal Denervation, Medtronic. “We will continue to strengthen our leadership position in renal denervation therapy with additional research, including similar economic and clinical analyses in additional countries.”
Source: Medtronic, Inc.